What are the main causes of prostatitis?
The causes of prostatitis vary depending on the form of the disease.
Acute bacterial prostatitis
Acute bacterial prostatitis is caused by a bacterial infection. Common triggers are:
Gut bacteria: Especially Escherichia coli, which ascend from the urinary tract or intestines into the prostate.
Urinary tract infections: Bacteria enter the prostate via the urethra.
Catheterization or interventions: Urinary catheters or medical procedures can introduce germs.
Chronic bacterial prostatitis
This form of prostatitis usually develops from an incompletely healed acute infection. Bacteria can persist in the prostate and cause recurring symptoms.
Chronic abacterial prostatitis (CPPS)
The exact cause of CPPS is unclear. Discussed triggers include:
Muscle tension: Tension in the pelvic floor area can lead to chronic pain.
Nerve irritation: Irritation of the nerves supplying the prostate plays a role.
Autoimmune reactions: Misguided immune reactions can lead to inflammation.
Psychological factors: Stress and anxiety can worsen symptoms.
Asymptomatic prostatitis
This form of prostatitis usually goes unnoticed and is diagnosed incidentally, for example through elevated PSA levels or during infertility examinations.

Which bacteria cause prostate inflammation?
In bacterial prostatitis – both acute and chronic forms – certain bacteria are the main triggers. They usually enter the prostate via the urethra or bloodstream. The most common pathogens include:
|
Type of bacteria |
Occurrence/Origin |
|
Escherichia coli (E. coli) |
The most common pathogen originates from the intestinal tract. |
|
Klebsiella |
Gut bacteria that occur in urinary tract infections. |
|
Proteus |
Bacteria from the gastrointestinal tract. |
|
Enterococci |
Part of the normal gut flora, problematic in immunodeficiency. |
|
Pseudomonas aeruginosa |
Common in catheterized or hospitalized patients. |
|
Staphylococci |
Especially Staphylococcus aureus, according to Operations or skin infections. |
|
Chlamydia |
Sexually transmitted bacteria that cause inflammation. |
|
Mycoplasmas and Ureaplasmas |
Sexually transmitted pathogens, atypical infections. |
How do bacteria get into the prostate?
Ascending infections: Bacteria from the urethra or bladder migrate into the prostate.
Bloodstream: Bacteria from other infection sites reach the prostate via the bloodstream.
Direct inoculation: During medical procedures such as catheterization or prostate biopsies.
Backflow of infected urine: Infected urine flows back into the prostate ducts and causes inflammation.
How does chronic abacterial prostatitis (CPPS) develop?
Chronic abacterial prostatitis, also known as chronic pelvic pain syndrome (CPPS), is the most common form of prostatitis. Unlike bacterial forms, no pathogens are detectable here. The exact cause of CPPS is not yet clearly understood, but several factors play a role in its development.
|
Cause/factor |
Explanation |
|
Muscle tension |
Chronic tension of the pelvic floor muscles can cause pain and stiffness. |
|
Nerve irritation |
Irritation of nerve pathways in the pelvic area can lead to persistent pain. |
|
Autoimmune reactions |
The immune system mistakenly reacts to the body's own tissue, causing inflammatory processes. |
|
Urine reflux |
Backflow of urine into the prostate ducts can cause chemical irritation and trigger pain. |
|
Hormonal disorders |
Hormonal imbalances can contribute to inflammatory reactions and discomfort. |
|
Psychosomatic factors |
Stress, anxiety, or depression worsen symptoms and increase muscle tension. |
|
Unrecognized infections |
Atypical pathogens such as chlamydia or mycoplasma can rarely trigger the symptoms. |
Mechanisms of pain development
tension and trigger points: Chronic muscle tension in the pelvic floor causes Myofascial pain, radiating into the perineum, groin, and lower abdominal region.
Neuropathic irritation: Overstimulated nerve fibers lead to persistent pain, which often worsens with physical exertion or sitting.
Inflammatory processes: Although no bacteria are detectable, inflammatory cells or chemical irritants (e.g., uric acid) can irritate the prostate and surrounding tissues.
Symptom relief through CANNEFF® SUP
In chronic abacterial prostatitis, CANNEFF® SUP suppositories can relieve symptoms. The combination of CBD and hyaluronic acid works:
anti-inflammatory: Alleviates local inflammation in the rectum, the rectum, and the adjacent tissue (e.g., the prostate).
pain-relieving: Soothes irritated nerves and mucous membranes.
muscle-relaxing: Relieves tension in the pelvic floor area, which is often the main cause of the complaints.
CPPS symptoms often overlap with conditions such as anal burning, anal fissures, or bladder infections. Therefore, thorough medical evaluation is important to rule out other causes. Read more here about the symptoms of prostatitis as well as diagnosis and the doctor's visit for prostatitis.

Can urinary tract infections lead to prostatitis?
Yes, urinary tract infections (UTIs) can lead to prostatitis, especially acute bacterial prostatitis. The bacteria causing a urinary tract infection can ascend through the urethra and reach the prostate. There they cause infection and inflammation.
How does prostatitis develop from urinary tract infections?
Ascending infection: Bacteria such as Escherichia coli or enterococci, common pathogens of UTIs, migrate through the urethra into the prostate.
Reflux of infected urine: In bladder emptying disorders, infected urine can flow back into the prostate ducts. This irritates the tissue and promotes infection.
Residual urine formation: Incomplete bladder emptying (e.g., with an enlarged prostate) creates ideal conditions for bacterial growth.
|
Factor |
Explanation |
|
Urinary retention |
Urine retention increases the risk of infection. |
|
Urinary catheter |
Facilitates the entry of bacteria into the urinary tract and prostate. |
|
Weakened Immune System |
Increases susceptibility to infections. |
|
Sexually transmitted infections |
Chlamydia or gonococci can infect the urinary tract and prostate. |
|
Prostate hyperplasia (BPH) |
An enlarged prostate promotes residual urine formation and UTIs. |
Symptoms of prostatitis caused by urinary tract infections
Burning during urination (dysuria)
Frequent urge to urinate with low urine volume
Pain in the perineal, lower abdominal, or back area
Fever and chills (in acute bacterial prostatitis)
Treatment and complementary measures
Antibiotic therapyIn bacterial prostatitis, antibiotics such as fluoroquinolones or cotrimoxazole are the treatment of choice.
Supportive therapies: Painkillers, alpha blockers, and heat treatments relieve symptoms.
CANNEFF® SUP suppositories: In chronic non-bacterial prostatitis (CPPS), these suppositories can additionally relieve symptoms as they act locally anti-inflammatory and soothe the mucous membranes. Read more here about the treatment of prostatitis with suppositories.
Untreated urinary tract infections not only increase the risk of prostatitis but can also lead to further complications such as bladder infections, anal fissures, or anal burning. Early treatment is crucial. Read more here about the treatment of prostatitis.
What role does the immune system play in the development of prostatitis?
The immune system plays a crucial role in the development and course of prostatitis. In bacterial prostatitis, the immune system reacts to invading pathogens like E. coli or enterococci with an inflammatory response to fight the infection. In this process, inflammatory mediators are released, causing symptoms such as pain and swelling.
In chronic non-bacterial prostatitis (CPPS), however, the immune system appears to be misdirected. Experts suspect that an excessive immune response or autoimmune processes trigger inflammation of the prostate without detectable pathogens. Stress or chronic irritation of the pelvic floor can further amplify the immune response.
A weakened immune system (e.g., due to diabetes or chronic stress) increases the risk of infections and inflammation. In CPPS, anti-inflammatory measures like CANNEFF® SUP suppositories can alleviate symptoms by calming the tissue and reducing local immune reactions.

Is prostatitis a result of stress or psychological strain?
Yes, stress and psychological burdens can play a role in the development and course of prostatitis, especially chronic abacterial prostatitis (CPPS). Stress often leads to tense pelvic floor muscles, which can impair blood flow and increase pain in the pelvic area. Additionally, stress affects the immune system, increasing susceptibility to inflammatory reactions.
Psychological factors such as anxiety or depressive moods can intensify the perception of pain and increase suffering. Therefore, stress reduction and psychotherapeutic measures like cognitive behavioral therapy are important parts of treatment. Additionally, CANNEFF® SUP suppositories, which have anti-inflammatory and regenerative effects, can help relieve symptoms and improve quality of life. Read more here about the treatment of prostatitis.

How do urinary catheters and medical procedures affect the prostate?
Urinary catheters and medical procedures, such as a prostate biopsy or urethral instrumentation, can irritate the prostate and cause micro-injuries. This promotes the entry of bacteria into the prostate ducts and can trigger acute bacterial prostatitis. Additionally, catheters increase the risk of urinary tract infections, which can spread to the prostate. Careful hygiene and targeted use of catheters are therefore essential to prevent infections.
Are there genetic risk factors for prostatitis?
Genetic risk factors for prostatitis have not yet been clearly established, but studies suggest that hereditary predispositions may play a role. Men with a family history of prostate diseases or inflammatory conditions may have an increased risk of developing prostatitis. Additionally, genetic variations that affect the immune system or inflammatory response could increase susceptibility to chronic forms such as chronic abacterial prostatitis (CPPS). Read more here about various measures for preventing prostatitis.